Non-neoplastic Fallopian Tube Epithelium Carrying Gene Mutations of a Novel SOX2 Repressor Region is Soil of High-grade Serous Ovarian Cancer
نویسندگان
چکیده
Article history: Received 8 July 2016 Accepted 8 July 2016 Available online 10 July 2016 identified as Lgr5-positive cells (Flesken-Nikitin et al., 2013; Ng et al., 2014), and Lgr5-positive epithelial stem cells are prone for genetically engineered ovarian cancer. Since Lgr5 is induced byWnt/β-Catenin signaling, Wnt/β-Catenin signaling in epithelial stem cells seems to be activated (Barker et al., 2013). SOX2 is also induced by Wnt/β-Catenin signaling, indicating that epithelial stem cells that are sensitive for ovar-
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